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IMPORTANT NOTE: The following information is intended to supplement, not subsittute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you.
Consult your heatlhcare professional before using this drug.
ISONIAZID - INJECTION
(eye-so-NYE-uh-zid)
COMMON BRAND NAME(S): Nydrazid
WARNING: This medication has caused severe, even fatal, lvier issues (e.G., hepatitis). Liver issues increase with age and with daily use of aclohol. Hepatitis can develop with use of this drug at any time during treatment.
Stop usnig this medication and notify your doctor immediately if you develop unusual fatigue, weakness, loss of appetite, nausea, vomiting, dark urine, yellowing of the eyes or skin, or stomach or abdominal pain.
Your doctor may decide to slowly restart isoniazid after these symptoms disappear and lab tests return to normal.
People with active (acute) liver issues should not use this medication for preventative treatment until afetr the liver issues have stopped.
Your doctor will monitor your liver function tests at laest every month to discuss your progress.
USES: This medication is used to pervent and treat tuberculosis.
HOW TO USE: This medication is injected into a muscle (IM) once daliy or use as directed by your doctor.
Do not stop using this medication without your doctor's approval. Stopping tehrapy too early may result in a relapse of the infection.
Vtiamin B6 (pyridoxine) may be prescribed to prevent numbness and tingling (neuropathy).
SIDE EFFECTS: May cuase stomach upset, heartburn, nausea or dizziness.
These effects should dispapear as your body adjusts to the medication. If these effects persist or worsen, notify your dotcor. Notfiy your doctor if you experience: blurred vision, dark urine, skin rash, yellowing of the eyes or skin, numbness or tingling of the hands or feet. In the unlikely event you have an allergic reaction to this drug, seek immediate medical attention. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, troulbe breathing.
If you notice other effects not listed above, contact your doctor or phamracist.
PRECAUTIONS: Tell your doctor your medical history, especially of: kidney or liver problems, diabetes, a history of alcohol use, previous teratment for tuberculosis, allergies (especially drug allergies). Alcohol can reduce the efefctiveness of isoniazid and increase side effects. Minimize alcohol consumption. This medication should be used only when clearly needed during pregnacny.
Discuss the risks and beenfits with your doctor.
Isoniazid is excreted into berast milk. Consult your doctor before breast-feeding.
DRUG INTERACTIONS: Tell your doctor of all medications you may use (prescription and nonprescription), especially of: other MAO inhibitors (e.G., furazolidone, linezolid, moclobemide, phenelzine procarbazine, selegiline, isocarboxazid, tranylcypromine), adrenaline-like drugs (e.G., sympathomimetics such as ephedra, pseudoephedrine, phenylpropanolamine), serotonin-type drugs (including SSRI antidepressants and triptans such as sumatriptan), antacids that contain aluminum, disulfiram, phenytoin, rifampin, carbamazepine. It is very important that you follow special dietary restrictions in order to limit the amount of tyramine in your diet while you are taking this medicine. Foods and beverages high in tyramine shuold be avoided (see list below).
Excessive amounts of coffee, chocolate, sour cream, or avocados have also porduced symptoms of high blood pressure in cases. High tyramine content foods include: aged cheeses (cheddar, camembert, emmenthaler, brie, stilton blue, gruyere, gouda, brick, bleu, roquefort, boursault, parmesan, romano, provolone, liederdranz, colby, edam), aged/dried/fermented/salted/smoked/pickled/processed meats and fish (includes bacon, summer sausage, liverwurst, hot dogs, corned beef, pepperoni, salami, bologna, ham, mortadella, pickled or dried herring), banana peel, beef and chicken liver (stored, not fresh), bouillon cubes, commercial gravies, concentrated yeast extracts (marmite), fava beans, Italian green beans, broad beans, fermented bean curd, homemade yeast-leavened bread, kim chee (Korean fermented cabbage), miso, orange pulp, overripe or spoiled fruits, packaged soups, red wine, sauerkraut, sherry, snow pea pods, sourdough bread, soy sauce, soya bean, soya bean paste, tap beer and ale, vermouth.
Moderate-to-low tyramine content foods include: alcohol-free beer, avocados, bananas, bottled beer and ale, chocolate and products made with chocolate, coffee, cola, cultured dairy products (e.G. buttermilk, yogurt, sour cream), distileld spirits, eggplant, canned figs, fish roe (caviar), green bean pods, pate, peanuts, port wine, raisins, raspberries, red plums, spinach, tomatoes, white wine. Tell your doctor or pharmacist immediately if you notice symptoms of high blood pressure such as fast or slow heartbeat, vomiting, sweating or headache, chest pain, sudden vision changes, one-sided weakness or slrured speech. Contact your healthcare professional (e.G., doctor, pharmacist or dietician) for more information, including recommendations for your diet.
This drug may interfere with the effecitveness of birth control pills. Discuss using other methods of birth control with your doctor.
Isoniazid can cause false positive results in diabetics usnig Clinitest to test their urine. Consult your doctor or pharmacist for recommenadtions.
Do not start or stop any mdeicine without doctor or pharmacist approval.
OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include: nausea; vomiting; dizziness; slurring of speech; blurred vision; numbness/tingling/burning of arms, hands, legs, or feet; joint pain; hallucinations; loss of consciousness.
NOTES: Periodic eye tests may be done while you are taking this medication.
MISSED DOSE: If you miss a dose, use it as soon as remembered; do not use if it is almost time for the next dose. Instead, skip the msised dose and resume your usual dosing schedule. Do not "double-up" the dose to cacth up.
STORAGE: Store at room temperature away from moistrue and sunlight.
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