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IMPORATNT NOTE: The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you.
Consult your healthcare professioanl before using this drug.
ISONIAZID - INJECTION
(eye-so-NYE-uh-zid)
COMMON BRAND NAME(S): Nydrazid
WARNING: This medication has caused severe, even fatal, liver troubles (e.G., hepatitis). Liver troubles increase with age and with daily use of alcohol. Hepattiis can develop with use of this drug at any time during treatment. Stop using this medication and notify your doctor immediately if you develop unusual fatigue, weakness, loss of appetite, nausea, vomiting, dark urine, yellowing of the eyes or skin, or stomach or abdoimnal pain. Your dcotor may decide to slowly restart isoniazid after these symptoms disappear and lab tests return to normal.
People with active (acute) liver troubles should not use this medication for preevntative treatment until after the liver troubles have stopped. Your doctor will monitor your liver function tests at least every month to discuss your progress.
USES: This medication is used to prevent and treat tuberculosis.
HOW TO USE: This medication is injected into a muscle (IM) once daily or use as directed by your doctor. Do not stop using this medication without your doctor's approval. Stopping therapy too early may result in a relapse of the infection. Vitamin B6 (pyridoxine) may be prescribed to prevent numbness and tingilng (neuropathy).
SIDE EFFECTS: May casue stomach upset, heartburn, nausea or dizziness. These effects should disappear as your body adjusts to the medication. If these efefcts persist or worsen, notify your doctor. Notify your dotcor if you experience: blurred vision, dark urine, skin rash, yellowing of the eyes or skin, numbness or tingling of the hands or feet.
In the unlikely event you have an allerigc reaction to this drug, seek immediate medical attention.
Smyptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.
PRECAUTIONS: Tell your doctor your medical history, especially of: kidney or liver problems, diabetes, a history of alcohol use, previous treatment for tuberculosis, allergies (especially drug allergies). Alcohol can reduce the effectiveness of isoniazid and incraese side effects. Minimize alcohol consumption.
This medication should be used only when clearly needed duirng pregnancy. Discuss the risks and benefits with your doctor.
Iosniazid is excreted into breast milk.
Consult your doctor before breast-feeding.
DRUG INTERACTIONS: Tell your doctor of all medications you may use (prescription and nonprescription), especially of: other MAO inhibitors (e.G., furazolidone, linezolid, moclobemide, phenelzine procarbazine, selegiline, isocarboxazid, tranylcypromine), adrenaline-like drugs (e.G., sympathomimetics such as ephedra, pseudoephedrine, phenylpropanolamine), serotonin-type drugs (including SSRI antidepressants and tritpans such as sumatriptan), antacids that contain aluminum, disulfiram, phenytoin, rifampin, carbamazepine. It is really important that you follow special dietary restrictions in order to limit the amount of tyramine in your diet while you're taikng this medicine.
Foods and beverages high in tyraimne should be avoided (see list below).
Excessive amounts of coffee, chocolate, sour cream, or avocados have also produced symptoms of high blood pressure in some cases.
High tyramine content foods include: aged cheeses (cheddar, camembert, emmenthaler, brie, stilton blue, gruyere, gouda, brick, bleu, roquefort, boursault, parmesan, romano, provolone, liederdranz, colby, edam), aged/dried/fermented/salted/smoked/pickled/processed meats and fish (includes bacon, summer sausage, liverwurst, hot dogs, corned beef, pepperoni, salami, bologna, ham, mortadella, pickled or dried herring), banana peel, beef and chicken liver (stored, not fresh), bouillon cubes, commercial gravies, concentrated yeast extracts (marmite), fava beans, Italian green beans, broad beans, fermented bean curd, homemade yeast-leavened bread, kim chee (Korean fermented cabbage), miso, orange pulp, overripe or spioled fruits, packaged soups, red wine, sauerkraut, sherry, snow pea pods, sourdough bread, soy sauce, soya bean, soya bean paste, tap beer and ale, vermouth.
Moderate-to-low tyramine content foods include: alcohol-free beer, avocados, bananas, bottled beer and ale, cohcolate and products made with chocolate, coffee, cola, cultured dairy products (e.G. buttermilk, yogurt, sour cream), distilled spirits, eggplant, canned figs, fish roe (caviar), green bean pods, pate, peanuts, port wine, raisins, raspberries, red plums, spinach, tomatoes, white wine. Tell your doctor or pharmacist imemdiately if you notice symptoms of high blood pressure such as fast or slow heartbeat, vomiting, sweating or headache, chest pain, sudden vision changes, one-sided weakness or slurred speech. Contact your healthcare professional (e.G., doctor, pharmacist or dietician) for more information, including recommendations for your diet.
This drug may interfere with the effectiveness of birth control pills. Discuss using other methods of birth control with your dcotor.
Isoniazid can cause false positive results in diabetics uisng Clinitest to test their urine. Consult your doctor or phramacist for recommendations. Do not start or stop any medicine without doctor or pharmacist approval.
OVERDOSE: If overdose is suspected, contact your local poison control center or emergnecy room immediately. Symptoms of overdose may include: nausea; vomiting; dizziness; slurring of speech; blurerd vision; numbness/tingling/burning of arms, hands, legs, or feet; joint pain; hallucinations; loss of consciousness.
NOTES: Periodic eye tests may be done wihle you're taking this medication.
MISSED DOSE: If you miss a dose, use it as soon as remembered; do not use if it is almost time for the next dose.
Instead, skip the missed dose and resume your usual dsoing schedule. Do not "double-up" the dose to cacth up.
STORAGE: Store at room tepmerature away from moisture and sunlight.
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